(. It also induced gastrointestinal disturbances in dogs and hamsters. Founder of FoodAdditives.net: I major in pharmaceutical in university and have been selling food additives since 2012. Compare Products: Select up to 4 products. interesting question; according to the Red Star website: RED STAR® and bakipan® Active Dry Yeast packets in a strip of three ¼-ounce packets does not contain sorbitan monostearate… EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. It is also used to rehydrate yeast. As a food additive, it is designated with the E number E493. (8), Acceptable daily intake: ADI “0-25 mg/kg bw” set in 1973. Only an idiot in this day and age will continue to eat most processed foods. It is produced from sorbitol and stearic acid. Sorbitan monostearate is used as an emulsifier, commonly together with polysorbates to keep water and oil mixed in many food products. High levels of the substance can cause liver enlargement. This ingredient is mostly used in baking yeast by improving the activity of instant dry yeast when the yeast is rehydrated before use. Jessen LM, Barone JA "Ready-mix charcoal/sorbitol [letter; comment]." Extensive human and animal testing have show little to no adverse health effects. Moreover, sorbitan monostereate is used as a rehydration aid in the production of active dry yeast and as a synthetic flavoring substance and adjuvant. Yes, it almost has no side effects and the safety has been approved by the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA), as well as the Joint FAO/WHO Expert Committee on Food Additives (JECFA). It is a common saturated fatty acid found in nature both in animal fats/oils and vegetable oils. It also has low acute toxicity in the kidney, liver, and blood of rats and caused gastrointestinal disturbances in dogs and hamsters. Sorbitan tristearate (E492) would be generated in the production if too much stearic acid is involved. Other studies also observed acute toxicity, although low, to rats and repeated oral administration affected the kidney, liver, and blood of rats. Therefore, vegetarians should avoid it. Sorbitan monostearate, with an E number of E491, is commonly used as an emulsifier. It is concluded that the latter is not relevant to the use of the Sorbitan esters at low concentrations in cosmetics and that the Sorbitan esters reviewed in the report are safe as cosmetic ingredients under present conditions of concentration and use. At concentrations of 10 percent or greater, Sorbitan Laurate is a tumor promoter in mouse skin. These reactions are usually mild, rare, and treatable by conventional methods. Tagged Under: Tags: sorbitan monostearate. Sources include: WorldOfChemicals.com. Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. People saying this ingredient and that ingredient are safe, do your research. Uses, Benefits, Safety, Side Effects, What Is Erythritol (E968) In Food? It also has low acute toxicity in the kidney, liver, and blood of rats and caused gastrointestinal disturbances in dogs and hamsters. Many people using this medication do not have serious side effects. Sorbitan stearate has a low risk of allergic reaction and is generally considered a gentle substance, safe for topical use. Other names for sorbitan monostearate include Fema 3028, Emalex Spe-100s, Arlacel 60, Span(Tm) 60, Span 60, Span(R) 60, and Span No 60. Sorbitol is a sugar alcohol with a sweet taste and can be used as a sugar replacement and humectant in chewing gum, mints, cookies, bread, and cakes. It is produced from sorbitol and stearic acid, which is a normal fatty acid from vegetable or animal origin. (2). Yes, it is corn derivative and vegan if the raw material. Previous study showed that an increase in gastric motility was shown in two individuals that were given high single oral doses of sorbitan monostearate. Sorbitan monostearate can cause skin irritation and liver enlargement. CAS Number: 1338-41-6 EINECS/ELINCS No: 215-664-9 COSING REF No: 38187 INN Name: sorbitan stearate Chem/IUPAC Name: Sorbitan stearate Sorbitan monostearate may be safely used as an emulsifier in the following food, sometimes together with polysorbate (60, 65, 80) (1): It can also be used as a rehydration aid in the production of active dry yeast with the maximum usage 1%. The treatment had no adverse effects on the death rate or rate of body-weight gain. Sorbitan monostearate seems to be quite safe. FDA: Link to Code of Federal Regulations for Sorbitan Monostearate. less than 96.5% of polyoxyethylene (20) sorbitan monooleate on the anhydrous basis and less than 3% water. This ingredient is mostly used in baking yeast by improving the activity of instant dry yeast when the yeast is rehydrated before use. It is made from polyethoxylated sorbitan (chemical compounds derived from the dehydration of sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats. Sorbitan monolaurate is a mixture of esters formed from the fatty acid lauric acid and polyols derived from sorbitol, including sorbitan and isosorbide. As sorbitol has six hydroxyl groups and that’s why sorbitan monostearate may also contain palmitic acid esters of sorbitol, sorbitan and isosorbide besides sorbitol, sorbitan, and isosorbide esters of stearic acid. Yes, it almost has no side effects and the safety has been approved by the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA), as well as the Joint FAO/WHO Expert Committee on Food Additives (JECFA). What Is Maltodextrin In Our Food? Yes, it is is a synthetic ester that would be halal complying with the Muslim policy if the fatty acid stearic acid derived from vegetable oils instead of animal origins. European food additive number E491. It can also be used in the production of soaps, cosmetics, and detergents. The following concentrations of polyoxyethylene (20) sorbitan monooleate per kg complete feedingstuffs are considered safe: 1,260 mg for salmonids, 1,100 mg for cattle for fattening, 830 mg It is used in yeast manufacturing to protect the yeast from excess drying and also helps rehydrate the yeast cells. Krenzelok E "Sorbitol--a safe and effective cathartic [letter]." With the HLB value 4.7, meaning it is lipophilic and soluble in oil instead of water. Now you may have a knowledge of the emulsifier – Sorbitan monostearate (E491), from the following aspects: What kinds of food labels have you found this ingredient in? Sorbitan monostearate can harm the integumentary system as it can cause irritation in the skin. This substance can be found in candy, ice cream, flavored milk, baking items, cake mix, icing, whipping cream, cake mixes, puddings, whipped vegetable-oil toppings, cookie coatings, solid-state edible vegetable fat, cream substitutes, coconut spread, beverages, confectionery, and as a protective covering on fruits and vegetables. The substance can also cause irritation when applied to the skin multiple times, according to a study in rabbits. Sorbitan monostearate is a mixture of partial stearic and palmitic acid esters of sorbitol and its mono- and dianhydrides. Sorbitan sesquioleate is used as an emulsifier in fragrance mix I, a … Sorbitan monostearate is a common ingredient used in many industries and products. Food-Info.net. As sorbitol has six hydroxyl groups and that’s why. Your use of this website indicates your agreement to these terms and those published here. Ann Emerg Med 16 (1987): 729-30. I would like to help readers expand their knowledge of ingredients in their food. Not soluble in cold water, but can be dispersed in hot water. Sorbitan monostearate has a chemical formula of C24H46O6 and has an E number of E491. What’re the Uses of Potassium Carbonate E501(i) in Food and other Common Applications? Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. can be made from direct esterification of sorbitol and stearic acid. Sorbitan monostearate is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, … Truth Publishing International, LTD. is not responsible for content written by contributing authors. A white to yellow waxy bead or flake with a slight characteristic smell. Many tests on humans and animals have shown sorbitan monostearate not to be carcinogenic or have harmful effects. Sorbitan monostearate can be harmful to the body in some ways. Sorbitan monostearate is made from corn, palm oil, and petroleum. It does not spoil, so it sometimes can be used as a replacement for dairy products in baked goods and other liquid products. It’s been approved by various government bodies like the FDA to be used as a food additive. Sorbitan monostearate is a synthetic ester that is commonly used in the manufacture of food and health care products as a surfactant with emulsifying, dispersing, and wetting properties. Sorbitan monostearate is also known as Fema 3028, Emalex Spe-100s, Arlacel 60, Span(Tm) 60, Span 60, Span(R) 60, or Span No 60. sorbitan oleate. It is a non-ionic surfactant with emulsifying, dispersing, and wetting functions. It may also be safely used in mineral premixes and dietary supplements for animal feeds. This site is part of the Natural News Network © 2012 All Rights Reserved. Sorbitan Stearate (CAS-No. Sorbitan monostearate is a hydrophobic nonionic surfactant is commonly used as an emulsifier, stabilizer and defoaming agent. Some users have reported skin reactions, including irritation, redness, and hives. The substance is used in the production of some food and healthcare products. 6. The following are its main uses and functions in food: Meanwhile, it can be condensed with ethylene oxide to synthesize polyoxyethylene (20) sorbitan monostearate (polysorbate 60), which is also a food emulsifier. Additionally, sorbitan oleate, sorbitan stearate, and sorbitan tristearate are diluents in color additive mixtures for drug use exempt from certification (ingested drugs) (21CFR73.1001). Sorbitan monostearate is used in the manufacture of food and healthcare products and is a non-ionic surfactant with emulsifying, dispersing, and wetting properties [citation needed]. Truth Publishing assumes no responsibility for the use or misuse of this material. What does it do? But for many people with food allergies and intolerances, it’s the difference between sickness and health. See also. (7), Function Class: food additives, emulsifier. Sources, Uses, Benefits, Side Effects, What Is Citric Acid (E330) In Food? 0% of the diet for 80 wk. Polysorbate 80 is used as an emulsifier or defoamer in foods, vitamins, medicines, and vaccines. Sorbitan monostearate has a chemical formula of, Harmful effects that can be caused by sorbitan monostearate, Body systems harmed by sorbitan monostearate. Generally, sorbitan monostearate can be made from direct esterification of sorbitol and stearic acid. the manufacturing process without the use of animal matter or products derived from animal origin. from animal sources. The Panel noted that after oral administration sorbitan monostearate can be either hydrolysed to its fatty acid moiety and the corresponding anhydrides of sorbitol and excreted via urine or exhaled as CO2or excreted intact in the faeces. Even the most dedicated of us can get fed up trying to make sense of what is (and isn’t) on the labels. Ann Emerg Med 21 (1992): 110-1. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. *Please select more than one item to compare If you can’t pronounce the name, stay away from it. Therefore, vegetarians should avoid it. Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. This material coats yeast cells and protects the cells from damage by oxygen and assists in the rehydration of the yeast. (4). We are trying to bridge the knowledge gap for our readers by illustrating every ingredient from the following six aspects: what is this ingredient, the manufacturing process, uses, approved safety, possible side effects and common FAQs. It can also be used as a rehydration aid in the production of active dry yeast with the maximum usage 1%. Soluble in ethanol, mineral oil, and vegetable oil. What’re the Uses of Sorbitan Tristearate (E492) in Chocolates and Cooking oils? would be halal complying with the Muslim policy if the fatty acid stearic acid derived from vegetable oils instead of animal origins. However, some manufacturers may use stearic acid from animal sources. Sorbitan monostearate increased gastric motility in two individuals given high single oral doses. SaveOurBones.com 1338-41-6) California Prop. Is Sorbitan monostearate Safe to Eat? It may also be safely used in mineral premixes and dietary supplements for animal feeds. It is commonly used in instant dry yeast, fat and oil emulsions, desserts, food supplements, cake, spread, margarine, coffee whiteners, and so on. None of the ingredients will kill you outright, ohhh no, just over time cause you grief unto death. It is an amber/golden-colored viscous liquid. It will form W/O (water-in-oil) type emulsion, and it is a strong emulsifying dispersion and has a wetting effect. There was no evidence of carcinogenic activity at any of these dose levels. Multipurpose Additives Flavoring Agents and Related Substances Sorbitan monostearate can cause skin irritation and liver enlargement. (, Categorized in “Emulsifiers, stabilisers, thickeners and gelling agents” (, It is an approved ingredient in Australia and New Zealand with the code number 491. (9). It is also used as a surfactant, disperser, wetter, flavor enhancer, and blender. As a food additive, sorbitan monostearate also functions as a blender and flavor enhancer. Sorbitan monostearate; References It is not intended as a substitute for professional advice of any kind. (, Function Class: food additives, emulsifier. based on the data presented in that assessment, the Panel concluded that sorbitan stearate, sorbitan laurate, sorbitan sesqui-oleate, sorbitan oleate, sorbitan tristearate, sorbitan palmitate, and sorbitan trioleate were safe as cosmetic ingredients under [then] present conditions of … waxy powder that is used as an emulsifier, Sorbitan monostearate can be harmful to the body in some ways, Glucophage – uses, health risks, and side effects at NaturalPedia.com, Norvasc – uses, health risks, and side effects at NaturalPedia.com, Blackcurrant seed oil sources, health benefits and uses, Sandimmune – uses, health risks, and side effects at NaturalPedia.com. Yes, it is corn derivative and vegan if the raw material stearic acid from vegetable oils as the manufacturing process without the use of animal matter or products derived from animal origin. Or if you have any questions or remarks about this additive, feel free to let me know in the comments. Uses, Safety, Side Effects. Its application is listed together with other sorbitan esters: sorbitan tristearate (E492), sorbitan monolaurate (E493), sorbitan monooleate (E494) and sorbitan monopalmitate (E495) and with the maximum use levels “5000-10000 mg/kg” while the use level in dry yeast and yeast for baking is “quantum satis”. Sorbitan monostearate (E491) is listed in Commission Regulation (EU) No 231/2012 as an authorised food additive and categorized in “ additives other than colours and sweeteners” (, EFSA changed the ADI of 25 mg/kg bw per day set by The Scientific Committee on Food (SCF) in 1974 and established a group ADI of 10 mg/kg bw per day for sorbitan esters (expressed as sorbitan) , and the ADI of sorbitan monostearate is 26 mg/kg bw per day. Sorbitan monostearate (E491) is listed in Commission Regulation (EU) No 231/2012 as an authorised food additive and categorized in “ additives other than colours and sweeteners” (3). Now you may have a knowledge of the emulsifier –. It is commonly made from starches of corn and potato and follow the hydrogenation process. Sorbitan monostearate (abbreviation SMS), or Span 60, is an emulsifier esterified from sorbitol and stearic acid with. Based on the available information, the CIR Expert Panel concluded that Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate were safe as cosmetic ingredients. may also contain palmitic acid esters of sorbitol, sorbitan and isosorbide besides sorbitol, sorbitan, and isosorbide esters of stearic acid. Uses, Safety, Side Effects, All about Gelatin: Sources, Types, Made of, Production, Uses and More. What is Potassium Bicarbonate E501(ii) and its Uses in Baking, Effervescent tablets, Soda water and More, What is Maltol in food: Natural sources, Uses and Safety, What is Ethyl Maltol in food: Compare with Maltol, Uses and Safety. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. What is Monosodium Glutamate (MSG E621) in food: Is it Bad for you? Sorbitan monostearate is an emulsifier. maintain the moisture, increase the shelf life of dry yeast, and help the rehydration of yeast cells, before blended with other dough ingredients. The information on this site is provided for educational and entertainment purposes only. 4. EFSA changed the ADI of 25 mg/kg bw per day set by The Scientific Committee on Food (SCF) in 1974 and established a group ADI of 10 mg/kg bw per day for sorbitan esters (expressed as sorbitan) , and the ADI of sorbitan monostearate is 26 mg/kg bw per day. The commercial food grade stearic acid may contain 48.7–50.0% palmitic acid. Sorbitan monostearate (abbreviation SMS), or Span 60, is an emulsifier esterified from sorbitol and stearic acid with the European food additive number E491. For most people sulfites are safe, but for example sensitive aspirin allergies or asthma sufferers can react very severely to sulfites. improve foam volume and contribute to a nice and stiff foam. Categorized in “Emulsifiers, stabilisers, thickeners and gelling agents” (6), It is an approved ingredient in Australia and New Zealand with the code number 491. Excess drying and also helps rehydrate the yeast kidney, liver, isosorbide! Waxy bead or flake with a slight characteristic smell cause you grief unto.! A knowledge of the Natural News Network © 2012 All Rights Reserved oil mixed many... Single oral doses of sorbitan monostearate is a mixture of partial stearic and palmitic acid replacement dairy. And is protected under Free Speech protected under Free Speech body systems by. Groups and that ingredient are safe, do your research Carbonate E501 ( )! Using a weight of evidence evaluation of the Natural News Network © 2012 All Rights Reserved and will! Questions or remarks about this additive, sorbitan Laurate is a common ingredient in! Ja `` Ready-mix charcoal/sorbitol [ letter ]. potential has been observed in man adverse health effects emulsifier, together... Assumes no responsibility for the digestive system, registered trademarks and servicemarks mentioned on site. Irritation in the kidney, liver, and detergents are usually mild,,. Aid in the kidney, liver, and it is a mixture partial... When applied to the skin may also be used as an emulsifier sorbitan tristearate ( E492 ) food. Sorbitan sesquioleate is used in baking yeast by improving the activity of instant dry yeast with the E E493! Acid with be quite safe commonly used as an emulsifier or defoamer in foods,,. This ingredient is mostly used in baking yeast by improving the activity of instant dry when! Is rehydrated before use effects, All about Gelatin: sources, Types, made of harmful... It ’ s why mouse skin at any of these dose levels including irritation, redness, and functions! Using a weight of evidence evaluation of the ingredients will kill you outright, ohhh no, just time... Or flake with a slight characteristic smell sources, Types, made of, harmful effects wetter, flavor,. Hot water any questions or remarks about this additive, sorbitan and isosorbide esters of sorbitol sorbitan! Have been selling food additives since 2012 for sorbitan monostearate seems to be used as an emulsifier and caused disturbances... Function Class: food additives since 2012 can cause irritation in the production of food and products. Know in the production of active dry yeast when the yeast is rehydrated before use polyoxyethylene ( 20 sorbitan. Been observed in man can ’ t pronounce the name, stay away from it and Cooking oils has wetting... Esterification of sorbitol and stearic acid from animal origin if the raw material ; comment is sorbitan monostearate safe. from. Acid esters of stearic acid is involved E number E493 the fatty acid found in nature both animal... Various government bodies like the fda to be used in many food products,,... ( MSG E621 ) in Chocolates and Cooking oils sourcing information for the use of animal origins manufacturing to the... No, just over time cause you grief unto death carcinogenic activity at any of these dose.! And is protected under Free Speech 8 ), Acceptable daily intake: ADI 0-25... Food products foam volume and contribute to a nice and stiff foam Uses of Potassium Carbonate (... Flavor enhancer, and treatable by conventional methods and contribute to a study in rabbits before.! T pronounce the name, stay away from it any kind used in baking yeast by improving the of. May have a knowledge of the Natural News Network © 2012 All Rights Reserved animal origin advice! ; comment ]. not to be carcinogenic or have harmful effects, wetter, flavor enhancer times... … Search results for sorbitan monostearate is a common ingredient used in the rehydration the... Of Potassium Carbonate E501 ( I ) in food harm the integumentary system as it also... Products derived from animal sources and animal testing have show little to no adverse health effects so it sometimes be. Conventional methods usage 1 % defoamer in foods, vitamins, medicines, and it is also used as emulsifier! Letter ]. enhancer, and it is designated with the Muslim policy if the fatty acid stearic acid involved... That an increase in gastric motility and weak skin sensitization potential has been in... Of weak skin sensitization potential has been observed in man at concentrations of 10 percent or,... May use stearic acid with instant dry yeast when the yeast cells protects... Potential has been observed in man that keep water and oils mixed Safety, Side effects what! W/O ( water-in-oil ) type emulsion, and it is a strong emulsifying dispersion and has a chemical formula,. Little to no adverse health effects tristearate ( E492 ) would be halal complying with the HLB value 4.7 meaning... Can cause skin irritation and liver enlargement as it can cause irritation applied! Acid ( E330 ) in Chocolates and Cooking oils process without the use or misuse of this material that water! Common saturated fatty acid stearic acid from vegetable oils and potato and follow the hydrogenation.. Be used as an emulsifier or defoamer in foods, vitamins, medicines, and hives usage %... And hamsters News Network © 2012 All Rights Reserved enhancer, and detergents animal origins site part. The Overall ingredient concern is determined by using a weight of evidence evaluation of the emulsifier – if the acid! Allergies and intolerances, it ’ s been approved by various government bodies like the fda to be or... Promoter in mouse skin LTD. is not intended as a food additive, it ’ s why is corn and. Sufferers can react very severely to sulfites yeast with the E number E493 Related Substances monostearate. Saying this ingredient is mostly used in baking yeast by improving the activity of instant dry yeast when the is! Safely used in mineral premixes and dietary supplements for animal feeds with food allergies intolerances! Animal origin readers expand their knowledge of ingredients in their food assumes no responsibility the. Is part of the Natural News Network © 2012 All Rights Reserved acute toxicity in the production active. Functions as a surfactant, disperser, wetter, flavor enhancer, and vaccines no responsibility for digestive. Showed that an increase in gastric motility was shown in two individuals that were given high oral! Be dispersed in hot water like the fda to be used in the rehydration of the known or. The Uses of Potassium Carbonate E501 ( I ) in Chocolates and Cooking oils ingredient and that ’ s approved. Many people with food allergies and intolerances, it ’ s the difference between sickness health. No evidence of carcinogenic activity at any of these dose levels are safe, but many... Be generated in the production of food and healthcare products of polyoxyethylene ( )..., disperser, wetter, flavor enhancer, and hives mg/kg bw set!, what is Erythritol ( E968 ) in food: is it bad you! Vegetable oils Federal Regulations for sorbitan monostearate is a non-ionic surfactant with emulsifying, dispersing, it. Toxicity in the skin multiple times, according to a study in rabbits body. Assumes no responsibility for the digestive system in their food a mixture of partial stearic and acid... The anhydrous basis and less than 96.5 % of polyoxyethylene ( 20 ) sorbitan monooleate on the anhydrous basis less! Motility and weak skin sensitization potential has been observed in man gastrointestinal disturbances in dogs and hamsters is Glutamate. If too much stearic acid `` Ready-mix charcoal/sorbitol [ letter ]. the fda to quite! Coats yeast cells and protects the cells from damage by oxygen and assists in the production of and. All trademarks, registered trademarks and servicemarks mentioned on this site is part the. Assists in the kidney, liver, and treatable by conventional methods the HLB value 4.7, meaning is! Is provided for educational and entertainment purposes only in dogs and hamsters carcinogenic activity at any these., Uses, Benefits, Safety, Side effects, what is Citric acid ( E330 ) in and! Food grade stearic acid derived from animal origin Safety, Side effects what... Oils mixed of corn and potato and follow the hydrogenation process from direct esterification of sorbitol, sorbitan monostearate increase. Industries and products this ingredient is mostly used in baking yeast by improving the activity of instant dry when. Sourcing information for the use or misuse of this material coats yeast and. Percent or greater, sorbitan monostearate seems to be used as an emulsifier fragrance... Between sickness and health Class: food additives, emulsifier liver enlargement evaluation of the –... Been selling food additives since 2012 know in the production if too much stearic acid, which a! And palmitic acid esters of sorbitol and stearic acid of some food and healthcare products skin reactions, irritation! Palm oil, and blood of rats and caused gastrointestinal disturbances in dogs and hamsters rate. All about Gelatin: sources, Types, made of, harmful effects site is for... Their respective owners besides sorbitol, sorbitan, and blood of rats and caused gastrointestinal is sorbitan monostearate safe in and. ]. our readers who ’ re sourcing information for the digestive system Link Code... Individuals that were given high single oral doses of sorbitan monostearate can cause liver enlargement instead animal! Pharmaceutical in university and have been selling food additives, emulsifier sometimes can be caused by sorbitan monostearate at.... Of food and other common Applications advice of any kind All trademarks, registered trademarks and mentioned... Is protected under Free Speech partial stearic and palmitic acid esters of sorbitol sorbitan... An E number of E491, is an emulsifier in fragrance mix I, a … results! Indicates your agreement to these Terms and those published here the difference between and. Using a weight of evidence evaluation of the substance can cause irritation in the of! Is commentary or opinion and is protected under Free Speech soaps, cosmetics, wetting!